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Methionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study
Lee, KY (Lee, Kang-Yun)[ 1,2 ]; Wong, CKC (Wong, Chris Kong-Chu)[ 3 ]; Chuang, KJ (Chuang, Kai-Jen)[ 4,5 ]; Bien, MY (Bien, Mauo-Ying)[ 1,6 ]; Cao, JJ (Cao, Jun-Ji)[ 7 ]; Han, YM (Han, Yong-Ming)[ 7 ]; Tian, LW (Tian, Linwei)[ 8 ]; Chang, CC (Chang, Chih-Cheng)[ 2 ]; Feng, PH (Feng, Po-Hao)[ 2 ]; Ho, KF (Ho, Kin-Fai)[ 8,9 ]; Chuang, HC (Chuang, Hsiao-Chi)[ 1,2 ]
2014-06-15
发表期刊JOURNAL OF HAZARDOUS MATERIALS
卷号274页码:384-391
文章类型期刊论文
摘要

The potential effects of inhaled fine particulate matter (PM2.5), found in haze episodes, on the oxidation of the proteins in the lungs are not well understood. We investigated the effects of PM2.5 from haze episodes on protein oxidation. PM2.5 was collected from the air pollution in Beijing (BJ), Xian (XA), Xiamen (XM) and Hong Kong (HK) during a period of intensive haze episodes. The chemical characteristics of these samples and their effects on albumin oxidation were investigated. The levels of PM2.5 in BJ and)CA were 4-6 times higher than in XM and HK. The concentrations of the polycyclic aromatic hydrocarbons (PAHs) components of the PM2.5 from BJ and XA were 10 times higher than those found in XM and HK. The haze PM2.5 increased oxidative stress. Addition of PM2.5 samples collected from haze episodes to albumin in vitro resulted in oxidation of methionine moieties; nasal instillation of PM2.5 suspensions in mice resulted in oxidation of methionine in the albumin in the bronchoalveolar lavage fluid. The methionine moieties participate in peptide chain crosslinking, and methionine oxidation in the albumin could be attributed to the PAH compounds. Our findings may be helpful in explaining the potential respiratory effects during haze episodes.

关键词Air Pollution Liquid Chromatography–mass Spectrometry Polycyclic Aromatic Hydrocarbons Protein Structure Pulmonary
DOI10.1016/j.jhazmat.2014.04.029
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/9737
专题粉尘与环境研究室
通讯作者Ho, KF (Ho, Kin-Fai)[ 8,9 ]; Chuang, HC (Chuang, Hsiao-Chi)[ 1,2 ]
作者单位1.School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan;
2.Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan;
3.State Key Laboratory in Marine Pollution-Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China;
4.School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan;
5.Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;
6.Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan;
7.Key Lab of Aerosol Science & Technology, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075, China;
8.The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China;
9.Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
推荐引用方式
GB/T 7714
Lee, KY ,Wong, CKC ,Chuang, KJ ,et al. Methionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study[J]. JOURNAL OF HAZARDOUS MATERIALS,2014,274:384-391.
APA Lee, KY .,Wong, CKC .,Chuang, KJ .,Bien, MY .,Cao, JJ .,...&Chuang, HC .(2014).Methionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study.JOURNAL OF HAZARDOUS MATERIALS,274,384-391.
MLA Lee, KY ,et al."Methionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study".JOURNAL OF HAZARDOUS MATERIALS 274(2014):384-391.
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