IEECAS OpenIR  > 粉尘与环境研究室
Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice
Chuang, Hsiao-Chi1,2; Ho, Kin-Fai3,4; Cao, Jun-Ji5; Chuang, Kai-Jen6,7; Ho, Steven Sai Hang8,9; Feng, Po-Hao2,10; Tian, Linwei11; Lee, Chii-Hong12; Han, Yong-Ming5; Lee, Chun-Nin1,2; Cheng, Tsun-Jen13,14
2015-09-17
Source PublicationTOXICOLOGY LETTERS
ISSN0378-4274
Volume237Issue:3Pages:174-180
SubtypeArticle
AbstractExposure to particulate matter less than 2.5 mu m (PM2.5) in size is an urgent issue for the protection of human health. Chemicals with PM2.5 collected during a period of intensive haze episodes in Beijing (BJ), Xian (XA) and Hong Kong (HK) were characterised for organic carbon (OC), elemental carbon (EC), total carbon (TC) and free amino acids. BALB/c mice underwent aspiration exposure of 50 or 150 mu g of PM2.5/mouse (BJ, XA and HK) on days 1 and 7 and were euthanised on day 14. The effects of these exposures on E-cadherin and inflammatory responses in the mouse lungs were analysed. The PM2.5 chemicals consisted of significant amounts of OC: 36.6 +/- 17.2 mu g/m(3) for BJ, 38.8 +/- 3.8 mu g/m(3) for XA and 7.2 +/- 1.4 mu g/m(3) for HK. A total of 23 free amino compounds for the PM2.5 samples were analysed: 4075 +/- 1578 pmol/m(3) for BJ, 4718 +/- 2190 pmol/m(3) for XA and 1145 +/- 213 pmol/m(3) for HK. Exposure to PM2.5 resulted in the suppression of E-cadherin levels in the lung tissues and increased IFN-gamma, IL-2, IL-4, IL-6 and IL-10 in the bronchoalveolar lavage fluid. The alterations in E-cadherin, IFN-gamma, IL-6 and IL-10 were associated with OC, TC and some amino acids, particularly non-protein-type amino acids. These data emphasised the deleterious health effects of PM2.5. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
KeywordAir Pollution Haze Physicochemistry Pm2.5 Organic Carbon Oxidative Stressair Pollution
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.toxlet.2015.06.013
WOS KeywordHAZE AIR-POLLUTION ; ALLERGIC SENSITIZATION ; HOSPITAL ADMISSIONS ; OXIDATIVE STRESS ; DIESEL EXHAUST ; FOG WATERS ; PARTICLES ; CELLS ; CALIFORNIA ; ALBUMIN
Indexed BySCI
Language英语
WOS Research AreaToxicology
WOS SubjectToxicology
WOS IDWOS:000358436500002
PublisherELSEVIER IRELAND LTD
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ieecas.cn/handle/361006/9290
Collection粉尘与环境研究室
Corresponding AuthorChuang, Hsiao-Chi
Affiliation1.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei 110, Taiwan
2.Taipei Med Univ, Shuang Ho Hosp, Div Pulm Med, Dept Internal Med, New Taipei City, Taiwan
3.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen Municipal Key Lab Hlth Risk Anal, Shenzhen, Peoples R China
5.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Sci & Technol, SKLLQG, Xian 710075, Peoples R China
6.Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth, Taipei 110, Taiwan
7.Taipei Med Univ, Coll Med, Sch Med, Dept Publ Hlth, Taipei 110, Taiwan
8.Chinese Acad Sci, Inst Earth Environm, SKLLQG, Beijing 100864, Peoples R China
9.Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA
10.Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei 110, Taiwan
11.Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China
12.Taipei Med Univ, Shuang Ho Hosp, Dept Pathol, New Taipei City, Taiwan
13.Taipei Med Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 110, Taiwan
14.Taipei Med Univ, Coll Publ Hlth, Inst Environm Hlth, Taipei 110, Taiwan
Recommended Citation
GB/T 7714
Chuang, Hsiao-Chi,Ho, Kin-Fai,Cao, Jun-Ji,et al. Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice[J]. TOXICOLOGY LETTERS,2015,237(3):174-180.
APA Chuang, Hsiao-Chi.,Ho, Kin-Fai.,Cao, Jun-Ji.,Chuang, Kai-Jen.,Ho, Steven Sai Hang.,...&Cheng, Tsun-Jen.(2015).Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice.TOXICOLOGY LETTERS,237(3),174-180.
MLA Chuang, Hsiao-Chi,et al."Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice".TOXICOLOGY LETTERS 237.3(2015):174-180.
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