IEECAS OpenIR  > 粉尘与环境研究室
Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice
Chuang, Hsiao-Chi1,2; Ho, Kin-Fai3,4; Cao, Jun-Ji5; Chuang, Kai-Jen6,7; Ho, Steven Sai Hang8,9; Feng, Po-Hao2,10; Tian, Linwei11; Lee, Chii-Hong12; Han, Yong-Ming5; Lee, Chun-Nin1,2; Cheng, Tsun-Jen13,14
2015-09-17
发表期刊TOXICOLOGY LETTERS
ISSN0378-4274
卷号237期号:3页码:174-180
文章类型Article
摘要Exposure to particulate matter less than 2.5 mu m (PM2.5) in size is an urgent issue for the protection of human health. Chemicals with PM2.5 collected during a period of intensive haze episodes in Beijing (BJ), Xian (XA) and Hong Kong (HK) were characterised for organic carbon (OC), elemental carbon (EC), total carbon (TC) and free amino acids. BALB/c mice underwent aspiration exposure of 50 or 150 mu g of PM2.5/mouse (BJ, XA and HK) on days 1 and 7 and were euthanised on day 14. The effects of these exposures on E-cadherin and inflammatory responses in the mouse lungs were analysed. The PM2.5 chemicals consisted of significant amounts of OC: 36.6 +/- 17.2 mu g/m(3) for BJ, 38.8 +/- 3.8 mu g/m(3) for XA and 7.2 +/- 1.4 mu g/m(3) for HK. A total of 23 free amino compounds for the PM2.5 samples were analysed: 4075 +/- 1578 pmol/m(3) for BJ, 4718 +/- 2190 pmol/m(3) for XA and 1145 +/- 213 pmol/m(3) for HK. Exposure to PM2.5 resulted in the suppression of E-cadherin levels in the lung tissues and increased IFN-gamma, IL-2, IL-4, IL-6 and IL-10 in the bronchoalveolar lavage fluid. The alterations in E-cadherin, IFN-gamma, IL-6 and IL-10 were associated with OC, TC and some amino acids, particularly non-protein-type amino acids. These data emphasised the deleterious health effects of PM2.5. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
关键词Air Pollution Haze Physicochemistry Pm2.5 Organic Carbon Oxidative Stressair Pollution
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.toxlet.2015.06.013
关键词[WOS]HAZE AIR-POLLUTION ; ALLERGIC SENSITIZATION ; HOSPITAL ADMISSIONS ; OXIDATIVE STRESS ; DIESEL EXHAUST ; FOG WATERS ; PARTICLES ; CELLS ; CALIFORNIA ; ALBUMIN
收录类别SCI
语种英语
WOS研究方向Toxicology
WOS类目Toxicology
WOS记录号WOS:000358436500002
出版者ELSEVIER IRELAND LTD
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/9290
专题粉尘与环境研究室
通讯作者Chuang, Hsiao-Chi
作者单位1.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei 110, Taiwan
2.Taipei Med Univ, Shuang Ho Hosp, Div Pulm Med, Dept Internal Med, New Taipei City, Taiwan
3.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen Municipal Key Lab Hlth Risk Anal, Shenzhen, Peoples R China
5.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Sci & Technol, SKLLQG, Xian 710075, Peoples R China
6.Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth, Taipei 110, Taiwan
7.Taipei Med Univ, Coll Med, Sch Med, Dept Publ Hlth, Taipei 110, Taiwan
8.Chinese Acad Sci, Inst Earth Environm, SKLLQG, Beijing 100864, Peoples R China
9.Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA
10.Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei 110, Taiwan
11.Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China
12.Taipei Med Univ, Shuang Ho Hosp, Dept Pathol, New Taipei City, Taiwan
13.Taipei Med Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 110, Taiwan
14.Taipei Med Univ, Coll Publ Hlth, Inst Environm Hlth, Taipei 110, Taiwan
推荐引用方式
GB/T 7714
Chuang, Hsiao-Chi,Ho, Kin-Fai,Cao, Jun-Ji,et al. Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice[J]. TOXICOLOGY LETTERS,2015,237(3):174-180.
APA Chuang, Hsiao-Chi.,Ho, Kin-Fai.,Cao, Jun-Ji.,Chuang, Kai-Jen.,Ho, Steven Sai Hang.,...&Cheng, Tsun-Jen.(2015).Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice.TOXICOLOGY LETTERS,237(3),174-180.
MLA Chuang, Hsiao-Chi,et al."Effects of non-protein-type amino acids of fine particulate matter on E-cadherin and inflammatory responses in mice".TOXICOLOGY LETTERS 237.3(2015):174-180.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Effects of non-prote(848KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chuang, Hsiao-Chi]的文章
[Ho, Kin-Fai]的文章
[Cao, Jun-Ji]的文章
百度学术
百度学术中相似的文章
[Chuang, Hsiao-Chi]的文章
[Ho, Kin-Fai]的文章
[Cao, Jun-Ji]的文章
必应学术
必应学术中相似的文章
[Chuang, Hsiao-Chi]的文章
[Ho, Kin-Fai]的文章
[Cao, Jun-Ji]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。