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Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China
Liu,S(Liu,Sha)1; Zhou,YM(Zhou,Yumin)1; Liu,SX(Liu,Suixin)2; Chen,XY(Chen,Xinyu)3; Zou,WF(Zou,Weifeng)4; Zhao,DX(Zhao,Dongxing)1; Li,XC(Li,Xiaochen)1; Pu,JD(Pu,Jinding)1; Huang,LM(Huang,Lingmei)1; Chen,JL(Chen,Jinlong)1; Li,B(Li,Bing)5; Liu,SL(Liu,Shiliang)6,7; Ran,PX(Ran,Pixin)1; Ran,Pixin
2017-09
发表期刊Chronic obstructive pulmonary disease
卷号72期号:9页码:788-795
文章类型期刊论文
摘要Objective The association between exposure to ambient particles with a median aerodynamic diameter less than 10/2.5 µm (particulate matter, PM10/2.5) and COPD remains unclear. Our study objective was to examine the association between ambient PM10/2.5 concentrations and lung functions in adults. Methods A cross-sectional study was conducted in southern China. Seven clusters were randomly selected from four cities across Guangdong province. Residents aged ≥20 years in the participating clusters were randomly recruited; all eligible participants were examined with a standardised questionnaire and spirometry. COPD was defined as a post-bronchodilator FEV1/FVC less than 70%. Atmosphere PM sampling was conducted across the clusters along with our survey. Results Of the subjects initially recruited, 84.4% (n=5993) were included for analysis. COPD prevalence and atmosphere PM concentration varied significantly among the seven clusters. COPD prevalence was significantly associated with elevated PM concentration levels: adjusted OR 2.416 (95% CI 1.417 to 4.118) for >35 and ≤75 µg/m3 and 2.530 (1.280 to 5.001) for >75 µg/m3 compared with the level of ≤35 µg/m3 for PM2.5; adjusted OR 2.442 (95% CI 1.449 to 4.117) for >50 and ≤150 µg/m3 compared with the level of ≤50 µg/m3 for PM1. A 10 µg/m3 increase in PM2.5 concentrations was associated with a 26 mL (95% CI −43 to −9) decrease in FEV1, a 28 mL (−49 to −8) decrease in FVC and a 0.09% decrease (−0.170 to −0.010) in FEV1/FVC ratio. The associations of COPD with PM10 were consistent with PM2.5 but slightly weaker. Conclusions Exposure to higher PM concentrations was strongly associated with increased COPD prevalence and declined respiratory function.
关键词Copd Epidemiology
DOI10.1136/thoraxjnl-2016-208910
收录类别SCI
所属项目编号2012BAI05B01 ; 81170043 ; 81470233 ; 20l5CB553403
语种英语
项目资助者Chinese central government key researchprojects of the 12th national five-year development plan ; Chinese central government key researchprojects of the 12th national five-year development plan ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Basic Research and Development Programme,973 Program ; National Key Basic Research and Development Programme,973 Program
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被引频次:162[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/5574
专题粉尘与环境研究室
通讯作者Ran,Pixin
作者单位1.The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
2.Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, China
3.Department of Pathogenic Biology, Guangzhou Medical University, Guangzhou, China
4.Guangzhou Chest Hospital, Guangzhou, Guangdong, China
5.The Research Center of Experimental Medicine, Guangzhou Medical University, Guangzhou, Guangdong, China
6.The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
7.School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa ON, Canada
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GB/T 7714
Liu,S,Zhou,YM,Liu,SX,et al. Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China[J]. Chronic obstructive pulmonary disease,2017,72(9):788-795.
APA Liu,S.,Zhou,YM.,Liu,SX.,Chen,XY.,Zou,WF.,...&Ran,Pixin.(2017).Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China.Chronic obstructive pulmonary disease,72(9),788-795.
MLA Liu,S,et al."Association between exposure to ambientparticulate matter and chronic obstructivepulmonary disease: results from a cross-sectionalstudy in China".Chronic obstructive pulmonary disease 72.9(2017):788-795.
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