| Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region | |
| Niu, Xinyi1,2; Ho, Steven Sai Hang2,3,4; Ho, Kin Fai5; Huang, Yu2,3; Sun, Jian6; Wang, Qiyuan2,3; Zhou, Yaqing2,3,7; Zhao, Zhuzi2,3; Cao, Junji2,3,8 | |
| 2017-12-01 | |
| Source Publication | ENVIRONMENTAL POLLUTION
 |
| Volume | 231Issue:Pt1Pages:1075-1084 |
| Subtype | Article |
| Abstract | The chemical composition of PM2.5 and cellular effects from exposure to fine aerosol extracts were studied for samples collected in Beijing, Tianjin, Shijiazhuang, and Hengshui, China in winter 2015. Effects of priority polycyclic aromatic hydrocarbons (PAHs) and their oxygenated derivatives (OPAHs) in PM2.5 on cell cultures were a major focus of the study. Total quantified PAHs and OPAHs at Shijiazhuang and Hengshui were higher than at Beijing and Tianjin, and benz(a)anthracene, chrysene and 1,8-naphthalic anhydride were the most abundant species. Exposure to PM2.5 extracts caused a concentration-dependent decline in cell viability and a dose-dependent increase in nitric oxide production. Two cytokines, tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), also increased when A549 test cells were exposed to PM2.5 extracts. PAHs and OPAHs in PM2.5 can potentially cause cell damage and induce cytotoxicity and pro-inflammatory responses: benzo(a)anthracene-7,12-dione was highly correlated with NO production, dibenz(a,h)anthracene and 1,4-chrysenequinone were correlated with TNF-alpha production, and 1-naphthaldehyde was significantly correlated with IL-6 production. The study provides a new approach for evaluating relationships between air-quality and cell toxicity with respect to specific chemicals. (C) 2017 Elsevier Ltd. All rights reserved. |
| Keyword | Pm2.5 Pahs Opahs Cytotoxicity |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1016/j.envpol.2017.08.099 |
| WOS Keyword | DIESEL EXHAUST PARTICLES ; CANCER-RISK ASSESSMENT ; PARTICULATE MATTER ; AIR-POLLUTION ; NITRIC-OXIDE ; AMBIENT AIR ; CHEMICAL-COMPOSITION ; SEASONAL-VARIATION ; OXIDATIVE STRESS ; NITRATED PAHS |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Environmental Sciences & Ecology |
| WOS Subject | Environmental Sciences |
| WOS ID | WOS:000414881000109 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ieecas.cn/handle/361006/5394 |
| Collection | 粉尘与环境研究室 |
| Affiliation | 1.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710061, Shaanxi, Peoples R China 3.Chinese Acad Sci, Inst Earth Environm, SKLLQG, Xian 710061, Shaanxi, Peoples R China 4.Desert Res Inst, Div Atmosphere Sci, Reno, NV 89512 USA 5.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China 6.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian, Shaanxi, Peoples R China 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 8.Xi An Jiao Tong Univ, Inst Global Environm Change, Xian, Shaanxi, Peoples R China |
| Recommended Citation GB/T 7714 | Niu, Xinyi,Ho, Steven Sai Hang,Ho, Kin Fai,et al. Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region[J]. ENVIRONMENTAL POLLUTION,2017,231(Pt1):1075-1084. |
| APA | Niu, Xinyi.,Ho, Steven Sai Hang.,Ho, Kin Fai.,Huang, Yu.,Sun, Jian.,...&Cao, Junji.(2017).Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region.ENVIRONMENTAL POLLUTION,231(Pt1),1075-1084. |
| MLA | Niu, Xinyi,et al."Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region".ENVIRONMENTAL POLLUTION 231.Pt1(2017):1075-1084. |
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| File Name/Size | DocType | Version | Access | License | ||
| Atmospheric levels a（1410KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | Application Full Text | |
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