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Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region
Niu, Xinyi1,2; Ho, Steven Sai Hang2,3,4; Ho, Kin Fai5; Huang, Yu2,3; Sun, Jian6; Wang, Qiyuan2,3; Zhou, Yaqing2,3,7; Zhao, Zhuzi2,3; Cao, Junji2,3,8
2017-12-01
发表期刊ENVIRONMENTAL POLLUTION
卷号231期号:Pt1页码:1075-1084
文章类型Article
摘要The chemical composition of PM2.5 and cellular effects from exposure to fine aerosol extracts were studied for samples collected in Beijing, Tianjin, Shijiazhuang, and Hengshui, China in winter 2015. Effects of priority polycyclic aromatic hydrocarbons (PAHs) and their oxygenated derivatives (OPAHs) in PM2.5 on cell cultures were a major focus of the study. Total quantified PAHs and OPAHs at Shijiazhuang and Hengshui were higher than at Beijing and Tianjin, and benz(a)anthracene, chrysene and 1,8-naphthalic anhydride were the most abundant species. Exposure to PM2.5 extracts caused a concentration-dependent decline in cell viability and a dose-dependent increase in nitric oxide production. Two cytokines, tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), also increased when A549 test cells were exposed to PM2.5 extracts. PAHs and OPAHs in PM2.5 can potentially cause cell damage and induce cytotoxicity and pro-inflammatory responses: benzo(a)anthracene-7,12-dione was highly correlated with NO production, dibenz(a,h)anthracene and 1,4-chrysenequinone were correlated with TNF-alpha production, and 1-naphthaldehyde was significantly correlated with IL-6 production. The study provides a new approach for evaluating relationships between air-quality and cell toxicity with respect to specific chemicals. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Pm2.5 Pahs Opahs Cytotoxicity
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.envpol.2017.08.099
关键词[WOS]DIESEL EXHAUST PARTICLES ; CANCER-RISK ASSESSMENT ; PARTICULATE MATTER ; AIR-POLLUTION ; NITRIC-OXIDE ; AMBIENT AIR ; CHEMICAL-COMPOSITION ; SEASONAL-VARIATION ; OXIDATIVE STRESS ; NITRATED PAHS
收录类别SCI
语种英语
WOS研究方向Environmental Sciences & Ecology
WOS类目Environmental Sciences
WOS记录号WOS:000414881000109
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/5394
专题粉尘与环境研究室
作者单位1.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710061, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Earth Environm, SKLLQG, Xian 710061, Shaanxi, Peoples R China
4.Desert Res Inst, Div Atmosphere Sci, Reno, NV 89512 USA
5.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China
6.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian, Shaanxi, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
8.Xi An Jiao Tong Univ, Inst Global Environm Change, Xian, Shaanxi, Peoples R China
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Niu, Xinyi,Ho, Steven Sai Hang,Ho, Kin Fai,et al. Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region[J]. ENVIRONMENTAL POLLUTION,2017,231(Pt1):1075-1084.
APA Niu, Xinyi.,Ho, Steven Sai Hang.,Ho, Kin Fai.,Huang, Yu.,Sun, Jian.,...&Cao, Junji.(2017).Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region.ENVIRONMENTAL POLLUTION,231(Pt1),1075-1084.
MLA Niu, Xinyi,et al."Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region".ENVIRONMENTAL POLLUTION 231.Pt1(2017):1075-1084.
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