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Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region
Niu, Xinyi1,2; Ho, Steven Sai Hang2,3,4; Ho, Kin Fai5; Huang, Yu2,3; Sun, Jian6; Wang, Qiyuan2,3; Zhou, Yaqing2,3,7; Zhao, Zhuzi2,3; Cao, Junji2,3,8
2017-12-01
Source PublicationENVIRONMENTAL POLLUTION
Volume231Issue:Pt1Pages:1075-1084
SubtypeArticle
AbstractThe chemical composition of PM2.5 and cellular effects from exposure to fine aerosol extracts were studied for samples collected in Beijing, Tianjin, Shijiazhuang, and Hengshui, China in winter 2015. Effects of priority polycyclic aromatic hydrocarbons (PAHs) and their oxygenated derivatives (OPAHs) in PM2.5 on cell cultures were a major focus of the study. Total quantified PAHs and OPAHs at Shijiazhuang and Hengshui were higher than at Beijing and Tianjin, and benz(a)anthracene, chrysene and 1,8-naphthalic anhydride were the most abundant species. Exposure to PM2.5 extracts caused a concentration-dependent decline in cell viability and a dose-dependent increase in nitric oxide production. Two cytokines, tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), also increased when A549 test cells were exposed to PM2.5 extracts. PAHs and OPAHs in PM2.5 can potentially cause cell damage and induce cytotoxicity and pro-inflammatory responses: benzo(a)anthracene-7,12-dione was highly correlated with NO production, dibenz(a,h)anthracene and 1,4-chrysenequinone were correlated with TNF-alpha production, and 1-naphthaldehyde was significantly correlated with IL-6 production. The study provides a new approach for evaluating relationships between air-quality and cell toxicity with respect to specific chemicals. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordPm2.5 Pahs Opahs Cytotoxicity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.envpol.2017.08.099
WOS KeywordDIESEL EXHAUST PARTICLES ; CANCER-RISK ASSESSMENT ; PARTICULATE MATTER ; AIR-POLLUTION ; NITRIC-OXIDE ; AMBIENT AIR ; CHEMICAL-COMPOSITION ; SEASONAL-VARIATION ; OXIDATIVE STRESS ; NITRATED PAHS
Indexed BySCI
Language英文
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000414881000109
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ieecas.cn/handle/361006/5394
Collection粉尘与环境研究室
Affiliation1.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710061, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Earth Environm, SKLLQG, Xian 710061, Shaanxi, Peoples R China
4.Desert Res Inst, Div Atmosphere Sci, Reno, NV 89512 USA
5.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China
6.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian, Shaanxi, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
8.Xi An Jiao Tong Univ, Inst Global Environm Change, Xian, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Niu, Xinyi,Ho, Steven Sai Hang,Ho, Kin Fai,et al. Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region[J]. ENVIRONMENTAL POLLUTION,2017,231(Pt1):1075-1084.
APA Niu, Xinyi.,Ho, Steven Sai Hang.,Ho, Kin Fai.,Huang, Yu.,Sun, Jian.,...&Cao, Junji.(2017).Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region.ENVIRONMENTAL POLLUTION,231(Pt1),1075-1084.
MLA Niu, Xinyi,et al."Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region".ENVIRONMENTAL POLLUTION 231.Pt1(2017):1075-1084.
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