IEECAS OpenIR  > 黄土与第四纪地质国家重点实验室(2010~)
QUANTITATIVE MONITORING OF CEFRADINE IN HUMAN URINE USING A LUMINOL/SULFOBUTYLETHER-beta-CYCLODEXTRIN CHEMILUMINESCENCE SYSTEM
Shen, M. X.1; Tan, X. J.2; Song, Zh. H.3
2018-05-01
Source PublicationJOURNAL OF APPLIED SPECTROSCOPY
Volume85Issue:2Pages:327-334
SubtypeArticle
AbstractIn this paper, a sensitive, rapid, and simple flow-injection chemiluminescence (FI-CL) technique is described for determining cefradine in human urine and capsule samples at the picogram level. The results show that cefradine within 0.1-100.0 nmol/L quantitatively quenches the CL intensity of the luminol/sulfo butylether-beta-cyclodextrin (SBE-beta-CD) system, with a relative correlation coefficient r of 0.9931. Subsequently, the possible mechanism for the quenching phenomenon is discussed in detail using the FI-CL and molecular docking methods. The proposed CL method, with a detection limit of 0.03 nmol/L (3 sigma) and relative standard deviations < 3.0% (N = 7), is then implemented to monitor the excretion of cefradine in human urine. After orally administration, the cefradine reaches a maximum value of 1.37 +/- 0.02 mg/mL at 2.0 h in urine, and the total excretion is 4.41 +/- 0.03 mg/mL within 8.0 h. The absorption rate constant k(a), the elimination rate constant k(e), and the half-life t(1/2) are 0.670 +/- 0.008 h(-1), 0.744 +/- 0.005 h(-1), and 0.93 +/- 0.05 h, respectively.
KeywordCefradine Sulfobutylether-beta-cyclodextrin Luminol Chemiluminescence Flow Injection Technique
WOS HeadingsScience & Technology ; Technology
DOI10.1007/s10812-018-0652-2
WOS KeywordFLOW-INJECTION-CHEMILUMINESCENCE ; SULFIDE QUANTUM DOTS ; CEPHALOSPORIN ANTIBIOTICS ; LIQUID-CHROMATOGRAPHY ; DRUG-DELIVERY ; HUMAN PLASMA ; BEHAVIOR ; SPECTROMETRY ; CEPHRADINE ; COMPLEX
Indexed BySCI
Language英语
WOS Research AreaSpectroscopy
WOS SubjectSpectroscopy
WOS IDWOS:000431887200020
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Document Type期刊论文
Identifierhttp://ir.ieecas.cn/handle/361006/5164
Collection黄土与第四纪地质国家重点实验室(2010~)
Affiliation1.Chinese Acad Sci, Inst Earth Environm, 97 Yanxiang Rd, Xian 710061, Shaanxi, Peoples R China
2.Changan Univ, Coll Earth Sci & Land Resources, Xian, Shaanxi, Peoples R China
3.Northwest Univ, Coll Chem & Mat Sci, Xian 710069, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Shen, M. X.,Tan, X. J.,Song, Zh. H.. QUANTITATIVE MONITORING OF CEFRADINE IN HUMAN URINE USING A LUMINOL/SULFOBUTYLETHER-beta-CYCLODEXTRIN CHEMILUMINESCENCE SYSTEM[J]. JOURNAL OF APPLIED SPECTROSCOPY,2018,85(2):327-334.
APA Shen, M. X.,Tan, X. J.,&Song, Zh. H..(2018).QUANTITATIVE MONITORING OF CEFRADINE IN HUMAN URINE USING A LUMINOL/SULFOBUTYLETHER-beta-CYCLODEXTRIN CHEMILUMINESCENCE SYSTEM.JOURNAL OF APPLIED SPECTROSCOPY,85(2),327-334.
MLA Shen, M. X.,et al."QUANTITATIVE MONITORING OF CEFRADINE IN HUMAN URINE USING A LUMINOL/SULFOBUTYLETHER-beta-CYCLODEXTRIN CHEMILUMINESCENCE SYSTEM".JOURNAL OF APPLIED SPECTROSCOPY 85.2(2018):327-334.
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