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In-vitro oxidative potential and inflammatory response of ambient PM2.5 in a rural region of Northwest China: Association with chemical compositions and source contribution
Li, Jianjun1,7; Li, Jin1; Wang, Gehui2,3; Ho, Kin Fai4,5; Han, Jing6; Dai, Wenting1; Wu, Can2,3; Cao, Cong1; Liu, Lang1
Corresponding AuthorLi, Jianjun(lijj@ieecas.cn) ; Wang, Gehui(ghwang@geo.ecnu.edu.cn)
2022-04-01
Source PublicationENVIRONMENTAL RESEARCH
ISSN0013-9351
Volume205Pages:10
AbstractOverproduction of reactive oxygen species (ROS) induced by atmospheric particles and subsequent inflammatory responses are considered as one of the most important pathological mechanisms with regard to the adverse effects of air pollution exposure. In this study, fine particulate matter (PM2.5) samples were collected at a rural site in Guanzhong Basin, Northwest China, in both summer (August 3-23, 2016) and winter (January 5-February 1, 2017). Then, human bronchial epithelial BEAS-2B cells were exposed to the PM2.5, cultured for 24 h, and then assayed for particle-induced ROS and three inflammatory factors (tumor necrosis-alpha (TNF-alpha), interleukin-6 (IL-6), and interferon-gamma (IFN-gamma)) in vitro. The oxidative potential (OP) induced by winter PM2.5 samples was higher than that induced by summertime samples, whereas inflammatory values showed contrasting seasonal variations. Both OP and inflammatory factors were significantly correlated with most chemical compounds in winter, but not in summer, which was thought to be related mainly to the higher contribution from secondary aerosols formed during the warm season. Source apportionment results showed secondary aerosols formation have significant contribution to OP of PM2.5 in both seasons, but the dominant oxidation processes is different. Secondary nitrates-related process was the major contributors regulating the OP in winter; however, secondary sulfates formation were mainly responsible for the ROS responses in summer. For primary emission, biomass burning, rather than coal emission or vehicle exhaust, was the significant source for OP of PM2.5 in winter. In most cases, the source contribution of each inflammatory factor was similar to that of the ROS. Our results highlighted the significant health risk of atmospheric aerosols from biomass burning in the rural regions of Guanzhong Basin, Northwest China.
KeywordPM2.5 Source apportionment Oxidative stress Inflammatory response
DOI10.1016/j.envres.2021.112466
WOS KeywordSECONDARY ORGANIC AEROSOL ; HUMIC-LIKE SUBSTANCES ; PARTICULATE MATTER ; AIR-POLLUTION ; SIZE-DISTRIBUTIONS ; SEASONAL-VARIATION ; ATMOSPHERIC AEROSOLS ; PREMATURE MORTALITY ; SULFATE FORMATION ; FINE PARTICLES
Indexed BySCI ; SCI
Language英语
Funding ProjectStrategic Priority Research Program of the Chinese Academy of Sciences[XDB40000000] ; National Natural Science Foundation of China[41977332] ; National Natural Science Foundation of China[41773117] ; Innovation Capability Support Program of Shaanxi[2020KJXX-017] ; Youth Innovation Promotion Association CAS[2020407]
WOS Research AreaEnvironmental Sciences & Ecology ; Public, Environmental & Occupational Health
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; Innovation Capability Support Program of Shaanxi ; Youth Innovation Promotion Association CAS
WOS SubjectEnvironmental Sciences ; Public, Environmental & Occupational Health
WOS IDWOS:000730411900002
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ieecas.cn/handle/361006/17315
Collection粉尘与环境研究室
第四纪科学与全球变化卓越创新中心
Corresponding AuthorLi, Jianjun; Wang, Gehui
Affiliation1.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, SKLLQG, Xian 710061, Peoples R China
2.East China Normal Univ, Sch Geog Sci, Key Lab Geog Informat Sci, Minist Educ, Shanghai 200241, Peoples R China
3.Inst Ecochongming, 3663 N Zhongshan Rd, Shanghai 200062, Peoples R China
4.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
5.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen Municipal Key Lab Hlth Risk Anal, Shenzhen, Peoples R China
6.Xi An Jiao Tong Univ, Coll Publ Hlth, Hlth Sci Ctr, Xian 710061, Peoples R China
7.CAS Ctr Excellence Quaternary Sci & Global Change, Xian 710061, Peoples R China
Recommended Citation
GB/T 7714
Li, Jianjun,Li, Jin,Wang, Gehui,et al. In-vitro oxidative potential and inflammatory response of ambient PM2.5 in a rural region of Northwest China: Association with chemical compositions and source contribution[J]. ENVIRONMENTAL RESEARCH,2022,205:10.
APA Li, Jianjun.,Li, Jin.,Wang, Gehui.,Ho, Kin Fai.,Han, Jing.,...&Liu, Lang.(2022).In-vitro oxidative potential and inflammatory response of ambient PM2.5 in a rural region of Northwest China: Association with chemical compositions and source contribution.ENVIRONMENTAL RESEARCH,205,10.
MLA Li, Jianjun,et al."In-vitro oxidative potential and inflammatory response of ambient PM2.5 in a rural region of Northwest China: Association with chemical compositions and source contribution".ENVIRONMENTAL RESEARCH 205(2022):10.
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