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Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities
Sun, Jian1; Yu, Jinjin2; Shen, Zhenxing1; Niu, Xinyi3; Wang, Diwei1; Wang, Xin7; Xu, Hongmei1; Chuang, Hsiao-Chi5; Cao, Junji6; Ho, Kin-Fai4
通讯作者Shen, Zhenxing(zxshen@mail.xjtu.edu.cn)
2021-11-01
发表期刊ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
卷号224页码:10
摘要PM2.5 Road dust samples were collected from 10 representative cities in southern and northern China for examination of chemical components and oxidative stress levels in A549 cells. Downtown road dust was abundance of heavy metals, EC and PAHs compared to nondowntown road dust. Source apportionment also revealed the relative higher contribution of vehicle emission to downtown (35.8%) than nondowntown road dust (25.5%). Consequently, downtown road dust induced much higher intracellular reactive oxidative species (ROS) levels than that from nondowntown (p < 0.05). This study highlights that the ROS-inducing capacity of road dust in China is lower at lower latitudes, which resulted in a significantly higher ROS-inducing capacity of road dust from northern cities than southern ones. Hotspot analysis demonstrated that heavy metals (i.e., Cr, Zn, Cu and Pb) in road dust were the most closely associated with ROS production in A549 cells. Vehicle emission and combustion emission in road dust were identified to be correlated with cellular ROS production. The findings highlight the ROS-inducing effect of PM2.5 road dust and also serve as a reference to make the targeted solutions for urban road dust pollution control, especially from a public health perspective.
关键词Urban fugitive dust ROS PAH Heavy metal Source apportionment
DOI10.1016/j.ecoenv.2021.112680
关键词[WOS]POLYCYCLIC AROMATIC-HYDROCARBONS ; CHEMICAL SOURCE PROFILES ; FINE PARTICULATE MATTER ; SOURCE APPORTIONMENT ; FUGITIVE DUST ; HEAVY-METALS ; ASIAN DUST ; HEALTH-RISKS ; PM10 ; PAHS
收录类别SCI ; SCI
语种英语
资助项目Natural Science Foundation of Shaanxi Province, China[2019JQ-386] ; Natural Science Foundation of Shaanxi Province, China[2019JM-318] ; China Postdoctoral Science Foundation[2021M692549]
WOS研究方向Environmental Sciences & Ecology ; Toxicology
项目资助者Natural Science Foundation of Shaanxi Province, China ; China Postdoctoral Science Foundation
WOS类目Environmental Sciences ; Toxicology
WOS记录号WOS:000693097300007
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/16967
专题粉尘与环境研究室
通讯作者Shen, Zhenxing
作者单位1.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian 710049, Peoples R China
2.Xi An Jiao Tong Univ, Sch Pharm, Xian 710061, Peoples R China
3.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian 710049, Peoples R China
4.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
5.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan
6.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710075, Peoples R China
7.Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA
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GB/T 7714
Sun, Jian,Yu, Jinjin,Shen, Zhenxing,et al. Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,224:10.
APA Sun, Jian.,Yu, Jinjin.,Shen, Zhenxing.,Niu, Xinyi.,Wang, Diwei.,...&Ho, Kin-Fai.(2021).Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,224,10.
MLA Sun, Jian,et al."Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 224(2021):10.
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