| Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities | |
| Sun, Jian1; Yu, Jinjin2; Shen, Zhenxing1; Niu, Xinyi3; Wang, Diwei1; Wang, Xin7; Xu, Hongmei1; Chuang, Hsiao-Chi5; Cao, Junji6; Ho, Kin-Fai4 | |
| Corresponding Author | Shen, Zhenxing(zxshen@mail.xjtu.edu.cn) |
| 2021-11-01 | |
| Source Publication | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| ISSN | 0147-6513 |
| Volume | 224Pages:10 |
| Abstract | PM2.5 Road dust samples were collected from 10 representative cities in southern and northern China for examination of chemical components and oxidative stress levels in A549 cells. Downtown road dust was abundance of heavy metals, EC and PAHs compared to nondowntown road dust. Source apportionment also revealed the relative higher contribution of vehicle emission to downtown (35.8%) than nondowntown road dust (25.5%). Consequently, downtown road dust induced much higher intracellular reactive oxidative species (ROS) levels than that from nondowntown (p < 0.05). This study highlights that the ROS-inducing capacity of road dust in China is lower at lower latitudes, which resulted in a significantly higher ROS-inducing capacity of road dust from northern cities than southern ones. Hotspot analysis demonstrated that heavy metals (i.e., Cr, Zn, Cu and Pb) in road dust were the most closely associated with ROS production in A549 cells. Vehicle emission and combustion emission in road dust were identified to be correlated with cellular ROS production. The findings highlight the ROS-inducing effect of PM2.5 road dust and also serve as a reference to make the targeted solutions for urban road dust pollution control, especially from a public health perspective. |
| Keyword | Urban fugitive dust ROS PAH Heavy metal Source apportionment |
| DOI | 10.1016/j.ecoenv.2021.112680 |
| WOS Keyword | POLYCYCLIC AROMATIC-HYDROCARBONS ; CHEMICAL SOURCE PROFILES ; FINE PARTICULATE MATTER ; SOURCE APPORTIONMENT ; FUGITIVE DUST ; HEAVY-METALS ; ASIAN DUST ; HEALTH-RISKS ; PM10 ; PAHS |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | Natural Science Foundation of Shaanxi Province, China[2019JQ-386] ; Natural Science Foundation of Shaanxi Province, China[2019JM-318] ; China Postdoctoral Science Foundation[2021M692549] |
| WOS Research Area | Environmental Sciences & Ecology ; Toxicology |
| Funding Organization | Natural Science Foundation of Shaanxi Province, China ; China Postdoctoral Science Foundation |
| WOS Subject | Environmental Sciences ; Toxicology |
| WOS ID | WOS:000693097300007 |
| Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ieecas.cn/handle/361006/16967 |
| Collection | 粉尘与环境研究室 |
| Corresponding Author | Shen, Zhenxing |
| Affiliation | 1.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian 710049, Peoples R China 2.Xi An Jiao Tong Univ, Sch Pharm, Xian 710061, Peoples R China 3.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian 710049, Peoples R China 4.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China 5.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan 6.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710075, Peoples R China 7.Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA |
| Recommended Citation GB/T 7714 | Sun, Jian,Yu, Jinjin,Shen, Zhenxing,et al. Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,224:10. |
| APA | Sun, Jian.,Yu, Jinjin.,Shen, Zhenxing.,Niu, Xinyi.,Wang, Diwei.,...&Ho, Kin-Fai.(2021).Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,224,10. |
| MLA | Sun, Jian,et al."Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 224(2021):10. |
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