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Toxicological effects of personal exposure to fine particles in adult residents of Hong Kong
Chen, Xiao-Cui1,7; Chuang, Hsiao-Chi2; Ward, Tony J.3; Sarkar, Chinmoy1; Webster, Chris1; Cao, Junji4; Hsiao, Ta-Chih5; Ho, Kin-Fai6
通讯作者Ho, Kin-Fai(kfho@cuhk.edu.hk)
2021-04-15
发表期刊ENVIRONMENTAL POLLUTION
ISSN0269-7491
卷号275页码:10
摘要Toxicological studies have demonstrated the associations between fine particle (PM2.5) components and various cytotoxic endpoints. However, few studies have investigated the toxicological e?ects of source-specific PM2.5 at the individual level. To investigate the potential impact of source-specific PM2.5 on cytotoxic effects, we performed repeated personal PM2.5 monitoring of 48 adult participants in Hong Kong during the winter and summer of 2014-2015. Quartz filters were analyzed for carbonaceous aerosols and water-soluble ions in PM2.5. Teflon filters were collected to determine personal PM2.5 mass and metal concentrations. The toxicological effects of personal PM2.5 exposure-including cytotoxicity, inflammatory response, and reactive oxygen species (ROS) production-were measured using A549 cells in vitro. Personal PM(2.)5 samples collected in winter were more effective than those collected in summer at inducing cytotoxicity and the expression of proinflammation cytokine IL-6. By contrast, summer personal PM2.5 samples induced high ROS production. We performed a series of statistical analyses, Spearman correlation and a source apportionment approach with a multiple linear regression (MLR) model, to explore the sources contributing most significantly to personal PM2.5 bioreactivity. Secondary inorganic species and transition metals were discovered to be weak-to-moderately associated with cytotoxicity (r(s): 0.26-0.55; p < 0.01) and inflammatory response (r(s): 0.26-0.44; p < 0.05), respectively. Carbonaceous aerosols (i.e., organic and elemental carbon; r(s): 0.23-0.27; p < 0.05) and crustal material (Mg and Ca) was positively associated with ROS generation. The PMF-MLR models revealed that tailpipe exhaust and secondary sulfate contributed to ROS generation, whereas secondary nitrate was the major contributor to PM2.5 cytotoxicity and inflammation. These results improve and variate the arguments for practical policies designed to mitigate the risks posed by air pollution sources and to protect public health. (C) 2021 Elsevier Ltd. All rights reserved.
关键词Individual exposure Chemical components Cytotoxicity Interleukin-6 Reactive oxygen species (ROS)
DOI10.1016/j.envpol.2021.116633
收录类别SCI ; SCI
语种英语
资助项目National Natural Science Foundation of China[41907181] ; Research Grants Council of the Hong Kong Special Administrative Region of China[14203719]
WOS研究方向Environmental Sciences & Ecology
项目资助者National Natural Science Foundation of China ; Research Grants Council of the Hong Kong Special Administrative Region of China
WOS类目Environmental Sciences
WOS记录号WOS:000625380600041
出版者ELSEVIER SCI LTD
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/16196
专题粉尘与环境研究室
通讯作者Ho, Kin-Fai
作者单位1.Univ Hong Kong, HKUrbanLab, Hlth High Dens Cities Lab, Hong Kong, Peoples R China
2.Taipei Med Univ, Sch Resp Therapy, Coll Med, Taipei, Taiwan
3.Univ Montana, Sch Publ & Community Hlth Sci, Missoula, MT 59812 USA
4.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol, SKLLQG, Xian, Peoples R China
5.Natl Taiwan Univ, Grad Inst Environm Engn, Taipei, Taiwan
6.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
7.Univ Hong Kong, Shenzhen Inst Res & Innovat, Shenzhen, Peoples R China
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GB/T 7714
Chen, Xiao-Cui,Chuang, Hsiao-Chi,Ward, Tony J.,et al. Toxicological effects of personal exposure to fine particles in adult residents of Hong Kong[J]. ENVIRONMENTAL POLLUTION,2021,275:10.
APA Chen, Xiao-Cui.,Chuang, Hsiao-Chi.,Ward, Tony J..,Sarkar, Chinmoy.,Webster, Chris.,...&Ho, Kin-Fai.(2021).Toxicological effects of personal exposure to fine particles in adult residents of Hong Kong.ENVIRONMENTAL POLLUTION,275,10.
MLA Chen, Xiao-Cui,et al."Toxicological effects of personal exposure to fine particles in adult residents of Hong Kong".ENVIRONMENTAL POLLUTION 275(2021):10.
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