Genomic insights into the formation of human populations in East Asia

doi:10.1038/s41586-021-03336-2

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	Genomic insights into the formation of human populations in East Asia
	Wang, Chuan-Chao 1,2,3,4; Yeh, Hui-Yuan 5; Popov, Alexander N.6; Zhang, Hu-Qin 7; Matsumura, Hirofumi 8; Sirak, Kendra 2,9; Cheronet, Olivia 10; Kovalev, Alexey 11; Rohland, Nadin 2; Kim, Alexander M.2,12; Mallick, Swapan 2,3,13,14; Bernardos, Rebecca 2; Tumen, Dashtseveg 15; Zhao, Jing 7; Liu, Yi-Chang 16; Liu, Jiun-Yu 17; Mah, Matthew 13,14; Wang, Ke 3; Zhang, Zhao 2; Adamski, Nicole 2,14; Broomandkhoshbacht, Nasreen 2,14; Callan, Kimberly 2,14; Candilio, Francesca 10; Carlson, Kellie Sara Duffett 10; Culleton, Brendan J.18,19; Eccles, Laurie 20; Freilich, Suzanne 10; Keating, Denise 10; Lawson, Ann Marie 2,14; Mandl, Kirsten 10; Michel, Megan 2,14; Oppenheimer, Jonas 2; Ozdogan, Kadir Toykan 10; Stewardson, Kristin 2,14; Wen, Shaoqing 21; Yan, Shi 22; Zalzala, Fatma 2,14; Chuang, Richard 16; Huang, Ching-Jung 16; Looh, Hana 23; Shiung, Chung-Ching 16; Nikitin, Yuri G.24; Tabarev, Andrei V.25; Tishkin, Alexey A.26; Lin, Song 7; Sun, Zhou-Yong 27; Wu, Xiao-Ming 7; Yang, Tie-Lin 7; Hu, Xi 7; Chen, Liang 28; Du, Hua 29; Bayarsaikhan, Jamsranjav 30; Mijiddorj, Enkhbayar 31; Erdenebaatar, Diimaajav 31; Iderkhangai, Tumur-Ochir 31; Myagmar, Erdene 15; Kanzawa-Kiriyama, Hideaki 32; Nishino, Masato 33; Shinoda, Ken-ichi 33; Shubina, Olga A.34; Guo, Jianxin 1; Cai, Wangwei 35; Deng, Qiongying 36,37; Kang, Longli 38; Li, Dawei 39; Li, Dongna 40; Lin, Rong 38; Nini 38; Shrestha, Rukesh 4; Wang, Ling-Xiang 4; Wei, Lanhai 1; Xie, Guangmao 41,42; Yao, Hongbing 43; Zhang, Manfei 4; He, Guanglin 1; Yang, Xiaomin 1; Hu, Rong 1; Robbeets, Martine 44; Schiffels, Stephan 3; Kennett, Douglas J.45; Jin, Li 4; Li, Hui 4; Krause, Johannes 3; Pinhasi, Ron 10; Reich, David 2,9,13,14
通讯作者	Wang, Chuan-Chao(wang@xmu.edu.cn) ; Krause, Johannes(krause@shh.mpg.de) ; Pinhasi, Ron(ron.pinhasi@univie.ac.at) ; Reich, David(reich@genetics.med.harvard.edu)
	2021-03-18
发表期刊	NATURE
ISSN	0028-0836
卷号	591 期号:7850 页码:413-+
摘要	The deep population history of East Asia remains poorly understood owing to a lack of ancient DNA data and sparse sampling of present-day people(1,2). Here we report genome-wide data from 166 East Asian individuals dating to between 6000 BC and AD 1000 and 46 present-day groups. Hunter-gatherers from Japan, the Amur River Basin, and people of Neolithic and Iron Age Taiwan and the Tibetan Plateau are linked by a deeply splitting lineage that probably reflects a coastal migration during the Late Pleistocene epoch. We also follow expansions during the subsequent Holocene epoch from four regions. First, hunter-gatherers from Mongolia and the Amur River Basin have ancestry shared by individuals who speak Mongolic and Tungusic languages, but do not carry ancestry characteristic of farmers from the West Liao River region (around 3000 BC), which contradicts theories that the expansion of these farmers spread the Mongolic and Tungusic proto-languages. Second, farmers from the Yellow River Basin (around 3000 BC) probably spread Sino-Tibetan languages, as their ancestry dispersed both to Tibet-where it forms approximately 84% of the gene pool in some groups-and to the Central Plain, where it has contributed around 59-84% to modern Han Chinese groups. Third, people from Taiwan from around 1300 BC to AD 800 derived approximately 75% of their ancestry from a lineage that is widespread in modern individuals who speak Austronesian, Tai-Kadai and Austroasiatic languages, and that we hypothesize derives from farmers of the Yangtze River Valley. Ancient people from Taiwan also derived about 25% of their ancestry from a northern lineage that is related to, but different from, farmers of the Yellow River Basin, which suggests an additional north-to-south expansion. Fourth, ancestry from Yamnaya Steppe pastoralists arrived in western Mongolia after around 3000 BC but was displaced by previously established lineages even while it persisted in western China, as would be expected if this ancestry was associated with the spread of proto-Tocharian Indo-European languages. Two later gene flows affected western Mongolia: migrants after around 2000 BC with Yamnaya and European farmer ancestry, and episodic influences of later groups with ancestry from Turan.
DOI	10.1038/s41586-021-03336-2
收录类别	SCI ; SCI
语种	英语
资助项目	Far Eastern Federal University ; Institute of History, Archaeology and Ethnology Far Eastern Branch of the Russian Academy of Sciences ; RFBR[18-09-40101] ; Max Planck Society ; National Natural Science Foundation of China[NSFC 31801040] ; Nanqiang Outstanding Young Talents Program of Xiamen University[X2123302] ; National Social Science Foundation of China, a European Research Council (ERC)[20ZD248] ; National Social Science Foundation of China, a European Research Council (ERC)[ERC-2019-ADG-883700-TRAM] ; Fundamental Research Funds for the Central Universities[ZK1144] ; JSPS[16H02527] ; ERC under the European Union[646612] ; DFG[KR 4015/1-1] ; Baden Wurttemberg Foundation ; Max Planck Institute ; National Science Foundation (NSF)[BCS-1460369] ; NSF[BCS-1032255] ; NIH (NIGMS)[GM100233] ; Paul M. Allen Frontiers Group ; John Templeton Foundation[61220] ; [91731303] ; [31671297] ; [18490750300]
WOS研究方向	Science & Technology - Other Topics
项目资助者	Far Eastern Federal University ; Institute of History, Archaeology and Ethnology Far Eastern Branch of the Russian Academy of Sciences ; RFBR ; Max Planck Society ; National Natural Science Foundation of China ; Nanqiang Outstanding Young Talents Program of Xiamen University ; National Social Science Foundation of China, a European Research Council (ERC) ; Fundamental Research Funds for the Central Universities ; JSPS ; ERC under the European Union ; DFG ; Baden Wurttemberg Foundation ; Max Planck Institute ; National Science Foundation (NSF) ; NSF ; NIH (NIGMS) ; Paul M. Allen Frontiers Group ; John Templeton Foundation
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000630143700025
出版者	NATURE RESEARCH
引用统计
文献类型	期刊论文
条目标识符	http://ir.ieecas.cn/handle/361006/16125
专题	加速器质谱中心
通讯作者	Wang, Chuan-Chao; Krause, Johannes; Pinhasi, Ron; Reich, David
作者单位	1.Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Dept Anthropol & Ethnol,Inst Anthropol, Xiamen, Fujian, Peoples R China 2.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA 3.Max Planck Inst Sci Human Hist, Dept Archaeogenet, Jena, Germany 4.Fudan Univ, Sch Life Sci, Dept Anthropol & Human Genet, MOE Key Lab Contemporary Anthropol, Shanghai, Peoples R China 5.Nanyang Technol Univ, Sch Humanities, Nanyang, Singapore 6.Far Eastern Fed Univ, Sci Museum, Vladivostok, Russia 7.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian, Shaanxi, Peoples R China 8.Sapporo Med Univ, Sch Hlth Sci, Sapporo, Hokkaido, Japan 9.Harvard Univ, Dept Human Evolutionary Biol, Cambridge, MA 02138 USA 10.Univ Vienna, Dept Evolutionary Anthropol, Vienna, Austria 11.Russian Acad Sci, Inst Archaeol, Moscow, Russia 12.Harvard Univ, Dept Anthropol, Cambridge, MA 02138 USA 13.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA 14.Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA 15.Natl Univ Mongolia, Dept Anthropol & Archaeol, Ulaanbaatar, Mongolia 16.Natl Cheng Kung Univ, Inst Archaeol, Tainan, Taiwan 17.Univ Washington, Dept Anthropol, Seattle, WA 98195 USA 18.Penn State Univ, Inst Energy, University Pk, PA 16802 USA 19.Penn State Univ, Inst Environm, University Pk, PA 16802 USA 20.Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA 21.Fudan Univ, Inst Archaeol Sci, Shanghai, Peoples R China 22.Minzu Univ China, Sch Ethnol & Sociol, Beijing, Peoples R China 23.Acad Sinica, Inst Hist & Philol, Taipei, Taiwan 24.Russian Acad Sci, Far Eastern Branch, Inst Hist Archaeol & Ethnol, Museum Archaeol & Ethnol, Vladivostok, Russia 25.Russian Acad Sci, Siberian Branch, Inst Archaeol & Ethnog, Novosibirsk, Russia 26.Altai State Univ, Dept Archeol Ethnog & Museol, Barnaul, Russia 27.Shaanxi Prov Inst Archaeol, Xian, Shaanxi, Peoples R China 28.Northwest Univ, Sch Cultural Heritage, Xian, Shaanxi, Peoples R China 29.Chinese Acad Sci, Inst Earth Environm, Xian AMS Ctr, Xian, Shaanxi, Peoples R China 30.Natl Museum Mongolia, Res Ctr, Ulaanbaatar, Mongolia 31.Ulaanbaatar State Univ, Dept Archaeol, Ulaanbaatar, Mongolia 32.Natl Museum Nat & Sci, Dept Anthropol, Tsukuba, Ibaraki, Japan 33.Archaeol Ctr Chiba City, Chiba, Japan 34.Sakhalin Reg Museum, Dept Archeol, Yuzhno Sakhalinsk, Russia 35.Hainan Med Univ, Dept Biochem & Mol Biol, Haikou, Hainan, Peoples R China 36.Guangxi Med Univ, Dept Human Anat, Nanning, Peoples R China 37.Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Peoples R China 38.Xizang Minzu Univ Tibet Univ Nationalities, Sch Med, Minist Educ, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang, Peoples R China 39.Guangxi Univ Nationalities, Inst Hist & Culture Sci & Technol, Nanning, Peoples R China 40.Hainan Med Univ, Dept Biol, Haikou, Hainan, Peoples R China 41.Guangxi Normal Univ, Coll Hist Culture & Tourism, Guilin, Peoples R China 42.Guangxi Inst Cultural Relics Protect & Archaeol, Nanning, Peoples R China 43.Gansu Inst Polit Sci & Law, Key Lab Evidence Sci Gansu Prov, Belt & Rd Res Ctr Forens Mol Anthropol, Lanzhou, Gansu, Peoples R China 44.Max Planck Inst Sci Human Hist, Eurasia3angle Res Grp, Jena, Germany 45.Univ Calif Santa Barbara, Dept Anthropol, Santa Barbara, CA 93106 USA
推荐引用方式 GB/T 7714	Wang, Chuan-Chao,Yeh, Hui-Yuan,Popov, Alexander N.,et al. Genomic insights into the formation of human populations in East Asia[J]. NATURE,2021,591(7850):413-+.
APA	Wang, Chuan-Chao.,Yeh, Hui-Yuan.,Popov, Alexander N..,Zhang, Hu-Qin.,Matsumura, Hirofumi.,...&Reich, David.(2021).Genomic insights into the formation of human populations in East Asia.NATURE,591(7850),413-+.
MLA	Wang, Chuan-Chao,et al."Genomic insights into the formation of human populations in East Asia".NATURE 591.7850(2021):413-+.