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Cytotoxicity and Potential Pathway to Vascular Smooth Muscle Cells Induced by PM2.5 Emitted from Raw Coal Chunks and Clean Coal Combustion
Sun, Jian1; Shen, Zhenxing1; Niu, Xinyi2; Zhang, Yue1; Zhang, Bin1; Zhang, Tian1; He, Kun1; Xu, Hongmei1; Liu, Suixin3; Ho, Steven Sai Hang4; Li, Xuxiang5; Cao, Junji3
通讯作者Shen, Zhenxing(zxshen@mail.xjtu.edu.cn)
2020-11-17
发表期刊ENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
卷号54期号:22页码:14482-14493
摘要Coal combustion emits a large amount of PM2.5 (particulate matters with aerodynamic diameters less than 2.5 mu m) and causes adverse damages to the cardiovascular system. In this study, emissions from anthracite and bitumite were examined. Red mud (RM) acts as an additive and is mixed in coal briquettes with a content of 0-10% as a single variable to demonstrate the reduction in the PM2.5 emissions. Burnt in a regulated combustion chamber, the 10% RM-containing bitumite and anthracite briquettes showed 52.3 and 18.6% reduction in PM2.5, respectively, compared with their chunk coals. Lower cytotoxicity (in terms of oxidative stresses and inflammation factors) was observed for PM2.5 emitted from the RM-containing briquettes than those from non-RM briquettes, especially for the bitumite groups. Besides, the results of western blotting illustrated that the inhibition of NF-kappa B and MAPK was the potential pathway for the reduction of cytokine levels by the RM addition. The regression analyses further demonstrated that the reduction was attributed to the lower emissions of transition metals (i.e., Mn) and PAHs (i.e., acenaphthene). This pilot study provides solid evidence for the cytotoxicity to vascular smooth muscle cells induced by PM2.5 from coal combustion and potential solutions for reducing the emission of toxic pollutants from human health perspectives.
DOI10.1021/acs.est.0c02236
收录类别SCI ; SCI
语种英语
资助项目Natural Science Foundation of China[41907188] ; National Key R&D Program of China[2017YFC0212205] ; Natural Science Foundation of Shaanxi Province, China[2019JQ-386] ; China Postdoctoral Science Foundation[2019M653658]
WOS研究方向Engineering ; Environmental Sciences & Ecology
项目资助者Natural Science Foundation of China ; National Key R&D Program of China ; Natural Science Foundation of Shaanxi Province, China ; China Postdoctoral Science Foundation
WOS类目Engineering, Environmental ; Environmental Sciences
WOS记录号WOS:000592863400035
出版者AMER CHEMICAL SOC
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/15791
专题粉尘与环境研究室
通讯作者Shen, Zhenxing
作者单位1.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian 710049, Peoples R China
2.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Shatin, Hong Kong 999077, Peoples R China
3.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710049, Peoples R China
4.Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA
5.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian 710049, Peoples R China
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Sun, Jian,Shen, Zhenxing,Niu, Xinyi,et al. Cytotoxicity and Potential Pathway to Vascular Smooth Muscle Cells Induced by PM2.5 Emitted from Raw Coal Chunks and Clean Coal Combustion[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(22):14482-14493.
APA Sun, Jian.,Shen, Zhenxing.,Niu, Xinyi.,Zhang, Yue.,Zhang, Bin.,...&Cao, Junji.(2020).Cytotoxicity and Potential Pathway to Vascular Smooth Muscle Cells Induced by PM2.5 Emitted from Raw Coal Chunks and Clean Coal Combustion.ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(22),14482-14493.
MLA Sun, Jian,et al."Cytotoxicity and Potential Pathway to Vascular Smooth Muscle Cells Induced by PM2.5 Emitted from Raw Coal Chunks and Clean Coal Combustion".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.22(2020):14482-14493.
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