Cytotoxicity and Potential Pathway to Vascular Smooth Muscle Cells Induced by PM2.5 Emitted from Raw Coal Chunks and Clean Coal Combustion | |
Sun, Jian1; Shen, Zhenxing1; Niu, Xinyi2; Zhang, Yue1; Zhang, Bin1; Zhang, Tian1; He, Kun1; Xu, Hongmei1; Liu, Suixin3; Ho, Steven Sai Hang4; Li, Xuxiang5; Cao, Junji3 | |
通讯作者 | Shen, Zhenxing(zxshen@mail.xjtu.edu.cn) |
2020-11-17 | |
发表期刊 | ENVIRONMENTAL SCIENCE & TECHNOLOGY |
ISSN | 0013-936X |
卷号 | 54期号:22页码:14482-14493 |
摘要 | Coal combustion emits a large amount of PM2.5 (particulate matters with aerodynamic diameters less than 2.5 mu m) and causes adverse damages to the cardiovascular system. In this study, emissions from anthracite and bitumite were examined. Red mud (RM) acts as an additive and is mixed in coal briquettes with a content of 0-10% as a single variable to demonstrate the reduction in the PM2.5 emissions. Burnt in a regulated combustion chamber, the 10% RM-containing bitumite and anthracite briquettes showed 52.3 and 18.6% reduction in PM2.5, respectively, compared with their chunk coals. Lower cytotoxicity (in terms of oxidative stresses and inflammation factors) was observed for PM2.5 emitted from the RM-containing briquettes than those from non-RM briquettes, especially for the bitumite groups. Besides, the results of western blotting illustrated that the inhibition of NF-kappa B and MAPK was the potential pathway for the reduction of cytokine levels by the RM addition. The regression analyses further demonstrated that the reduction was attributed to the lower emissions of transition metals (i.e., Mn) and PAHs (i.e., acenaphthene). This pilot study provides solid evidence for the cytotoxicity to vascular smooth muscle cells induced by PM2.5 from coal combustion and potential solutions for reducing the emission of toxic pollutants from human health perspectives. |
DOI | 10.1021/acs.est.0c02236 |
收录类别 | SCI ; SCI |
语种 | 英语 |
资助项目 | Natural Science Foundation of China[41907188] ; National Key R&D Program of China[2017YFC0212205] ; Natural Science Foundation of Shaanxi Province, China[2019JQ-386] ; China Postdoctoral Science Foundation[2019M653658] |
WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
项目资助者 | Natural Science Foundation of China ; National Key R&D Program of China ; Natural Science Foundation of Shaanxi Province, China ; China Postdoctoral Science Foundation |
WOS类目 | Engineering, Environmental ; Environmental Sciences |
WOS记录号 | WOS:000592863400035 |
出版者 | AMER CHEMICAL SOC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ieecas.cn/handle/361006/15791 |
专题 | 粉尘与环境研究室 |
通讯作者 | Shen, Zhenxing |
作者单位 | 1.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian 710049, Peoples R China 2.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Shatin, Hong Kong 999077, Peoples R China 3.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710049, Peoples R China 4.Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA 5.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian 710049, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Jian,Shen, Zhenxing,Niu, Xinyi,et al. Cytotoxicity and Potential Pathway to Vascular Smooth Muscle Cells Induced by PM2.5 Emitted from Raw Coal Chunks and Clean Coal Combustion[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(22):14482-14493. |
APA | Sun, Jian.,Shen, Zhenxing.,Niu, Xinyi.,Zhang, Yue.,Zhang, Bin.,...&Cao, Junji.(2020).Cytotoxicity and Potential Pathway to Vascular Smooth Muscle Cells Induced by PM2.5 Emitted from Raw Coal Chunks and Clean Coal Combustion.ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(22),14482-14493. |
MLA | Sun, Jian,et al."Cytotoxicity and Potential Pathway to Vascular Smooth Muscle Cells Induced by PM2.5 Emitted from Raw Coal Chunks and Clean Coal Combustion".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.22(2020):14482-14493. |
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