IEECAS OpenIR  > 粉尘与环境研究室
Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong
Chen, Xiao-Cui1,10,11; Chuang, Hsiao-Chi2; Ward, Tony J.3; Tian, Linwei4; Cao, Jun-Ji5,6; Ho, Steven Sai-Hang12,13; Lau, Ngar-Cheung1,7; Hsiao, Ta-Chih9; Yim, Steve H. L.1,7; Ho, Kin-Fai1,8
Corresponding AuthorHo, Kin-Fai(kfho@cuhk.edu.hk)
2020-09-01
Source PublicationENVIRONMENTAL RESEARCH
ISSN0013-9351
Volume188Pages:13
AbstractDirect evidence about associations between fine particles (PM2.5) components and the corresponding PM2.5 bioreactivity at the individual level is limited. We conducted a panel study with repeated personal measurements involving 56 healthy residents in Hong Kong. Fractional exhaled nitric oxide (FeNO) levels were measured from these subjects. Out of 56 subjects, 27 (48.2%) participated in concurrent outdoor, indoor, and personal PM2.5 monitoring. Organic carbon (OC), elemental carbon (EC), particle bound-polycyclic aromatic hydrocarbons (PAHs), and phthalates were analyzed. Alteration in cell viability, lactic dehydrogenase (LDH), interleukin-6 (IL-6), and 8-isoprostane by 50 mu g/mL PM2.5 extracts was determined in A549 cells in vitro. Moderate heterogeneities were shown in PM2.5 exposures and the corresponding PM2.5 bioreactivity across different sample types. Associations between the analyzed components and PM2.5 bioreactivity were assessed using the multiple regression models. Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. Overall, OC in personal exposure played a dominant role in PM2.5-induced bioreactivity. Subsequently, we examined the associations of FeNO with IL-6 and 8-isoprostane levels using mixed-effects models. The results showed that per interquartile change in IL-6 and 8-isoprostane were associated with a 6.4% (p < 0.01) and 11.1% (p < 0.01) increase in FeNO levels, respectively. Our study explored the toxicological properties of chemical components in PM2.5 exposure, which suggested that residential indoors and personal OC and PAHs should be of great concern for human health. These findings indicated that further studies in inflammation and oxidative stress-related illnesses due to particle exposure would benefit from the assessment of in vitro PM2.5 bioreactivity.
KeywordOrganic carbon PAHs Inflammation Oxidative stress Biomarkers
DOI10.1016/j.envres.2020.109780
WOS KeywordFINE PARTICULATE MATTER ; POLYCYCLIC-AROMATIC-HYDROCARBONS ; OXIDATIVE STRESS ; AIR-POLLUTION ; PARTICLES PM2.5 ; INDOOR/OUTDOOR RELATIONSHIPS ; CIRCULATING BIOMARKERS ; CHINESE MEGACITY ; RISK-ASSESSMENT ; AMBIENT
Indexed BySCI ; SCI
Language英语
Funding ProjectResearch Grants Council of the Hong Kong Special Administrative Region of China[412413]
WOS Research AreaEnvironmental Sciences & Ecology ; Public, Environmental & Occupational Health
Funding OrganizationResearch Grants Council of the Hong Kong Special Administrative Region of China
WOS SubjectEnvironmental Sciences ; Public, Environmental & Occupational Health
WOS IDWOS:000564651700015
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ieecas.cn/handle/361006/15256
Collection粉尘与环境研究室
Corresponding AuthorHo, Kin-Fai
Affiliation1.Chinese Univ Hong Kong, Inst Environm Energy & Sustainabil, Hong Kong, Peoples R China
2.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan
3.Univ Montana, Sch Publ & Community Hlth Sci, Missoula, MT 59812 USA
4.Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China
5.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol, SKLLQG, Xian, Peoples R China
6.Xi An Jiao Tong Univ, Inst Global Environm Change, Xian, Peoples R China
7.Chinese Univ Hong Kong, Dept Geog & Resource Management, Hong Kong, Peoples R China
8.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
9.Natl Taiwan Univ, Grad Inst Environm Engn, Taipei, Taiwan
10.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China
11.Univ Hong Kong, Hlth High Dens Cities Lab, HKUrbanLab, Hong Kong, Peoples R China
12.Desert Res Inst, Div Atmosphere Sci, Reno, NV 89512 USA
13.Hong Kong Premium Serv & Res Lab, Kowloon, Cheung Sha Wan, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xiao-Cui,Chuang, Hsiao-Chi,Ward, Tony J.,et al. Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong[J]. ENVIRONMENTAL RESEARCH,2020,188:13.
APA Chen, Xiao-Cui.,Chuang, Hsiao-Chi.,Ward, Tony J..,Tian, Linwei.,Cao, Jun-Ji.,...&Ho, Kin-Fai.(2020).Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong.ENVIRONMENTAL RESEARCH,188,13.
MLA Chen, Xiao-Cui,et al."Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong".ENVIRONMENTAL RESEARCH 188(2020):13.
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