IEECAS OpenIR  > 粉尘与环境研究室
Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong
Chen, Xiao-Cui1,10,11; Chuang, Hsiao-Chi2; Ward, Tony J.3; Tian, Linwei4; Cao, Jun-Ji5,6; Ho, Steven Sai-Hang12,13; Lau, Ngar-Cheung1,7; Hsiao, Ta-Chih9; Yim, Steve H. L.1,7; Ho, Kin-Fai1,8
通讯作者Ho, Kin-Fai(kfho@cuhk.edu.hk)
2020-09-01
发表期刊ENVIRONMENTAL RESEARCH
ISSN0013-9351
卷号188页码:13
摘要Direct evidence about associations between fine particles (PM2.5) components and the corresponding PM2.5 bioreactivity at the individual level is limited. We conducted a panel study with repeated personal measurements involving 56 healthy residents in Hong Kong. Fractional exhaled nitric oxide (FeNO) levels were measured from these subjects. Out of 56 subjects, 27 (48.2%) participated in concurrent outdoor, indoor, and personal PM2.5 monitoring. Organic carbon (OC), elemental carbon (EC), particle bound-polycyclic aromatic hydrocarbons (PAHs), and phthalates were analyzed. Alteration in cell viability, lactic dehydrogenase (LDH), interleukin-6 (IL-6), and 8-isoprostane by 50 mu g/mL PM2.5 extracts was determined in A549 cells in vitro. Moderate heterogeneities were shown in PM2.5 exposures and the corresponding PM2.5 bioreactivity across different sample types. Associations between the analyzed components and PM2.5 bioreactivity were assessed using the multiple regression models. Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. Overall, OC in personal exposure played a dominant role in PM2.5-induced bioreactivity. Subsequently, we examined the associations of FeNO with IL-6 and 8-isoprostane levels using mixed-effects models. The results showed that per interquartile change in IL-6 and 8-isoprostane were associated with a 6.4% (p < 0.01) and 11.1% (p < 0.01) increase in FeNO levels, respectively. Our study explored the toxicological properties of chemical components in PM2.5 exposure, which suggested that residential indoors and personal OC and PAHs should be of great concern for human health. These findings indicated that further studies in inflammation and oxidative stress-related illnesses due to particle exposure would benefit from the assessment of in vitro PM2.5 bioreactivity.
关键词Organic carbon PAHs Inflammation Oxidative stress Biomarkers
DOI10.1016/j.envres.2020.109780
关键词[WOS]FINE PARTICULATE MATTER ; POLYCYCLIC-AROMATIC-HYDROCARBONS ; OXIDATIVE STRESS ; AIR-POLLUTION ; PARTICLES PM2.5 ; INDOOR/OUTDOOR RELATIONSHIPS ; CIRCULATING BIOMARKERS ; CHINESE MEGACITY ; RISK-ASSESSMENT ; AMBIENT
收录类别SCI ; SCI
语种英语
资助项目Research Grants Council of the Hong Kong Special Administrative Region of China[412413]
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
项目资助者Research Grants Council of the Hong Kong Special Administrative Region of China
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health
WOS记录号WOS:000564651700015
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/15256
专题粉尘与环境研究室
通讯作者Ho, Kin-Fai
作者单位1.Chinese Univ Hong Kong, Inst Environm Energy & Sustainabil, Hong Kong, Peoples R China
2.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan
3.Univ Montana, Sch Publ & Community Hlth Sci, Missoula, MT 59812 USA
4.Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China
5.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol, SKLLQG, Xian, Peoples R China
6.Xi An Jiao Tong Univ, Inst Global Environm Change, Xian, Peoples R China
7.Chinese Univ Hong Kong, Dept Geog & Resource Management, Hong Kong, Peoples R China
8.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
9.Natl Taiwan Univ, Grad Inst Environm Engn, Taipei, Taiwan
10.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China
11.Univ Hong Kong, Hlth High Dens Cities Lab, HKUrbanLab, Hong Kong, Peoples R China
12.Desert Res Inst, Div Atmosphere Sci, Reno, NV 89512 USA
13.Hong Kong Premium Serv & Res Lab, Kowloon, Cheung Sha Wan, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Chen, Xiao-Cui,Chuang, Hsiao-Chi,Ward, Tony J.,et al. Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong[J]. ENVIRONMENTAL RESEARCH,2020,188:13.
APA Chen, Xiao-Cui.,Chuang, Hsiao-Chi.,Ward, Tony J..,Tian, Linwei.,Cao, Jun-Ji.,...&Ho, Kin-Fai.(2020).Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong.ENVIRONMENTAL RESEARCH,188,13.
MLA Chen, Xiao-Cui,et al."Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong".ENVIRONMENTAL RESEARCH 188(2020):13.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Xiao-Cui]的文章
[Chuang, Hsiao-Chi]的文章
[Ward, Tony J.]的文章
百度学术
百度学术中相似的文章
[Chen, Xiao-Cui]的文章
[Chuang, Hsiao-Chi]的文章
[Ward, Tony J.]的文章
必应学术
必应学术中相似的文章
[Chen, Xiao-Cui]的文章
[Chuang, Hsiao-Chi]的文章
[Ward, Tony J.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。