IEECAS OpenIR  > 粉尘与环境研究室
Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong
Niu, Xinyi1; Chuang, Hsiao-Chi2; Wang, Xiaoliang3; Ho, Steven Sai Hang3,4; Li, Lijuan5,6,7; Qu, Linli4; Chow, Judith C.3; Watson, John G.3; Sun, Jian8; Lee, Shuncheng9; Cao, Junji5,6; Ho, Kin Fai1
Corresponding AuthorHo, Kin Fai(kfho@cuhk.edu.hk)
2020-08-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume263Pages:9
AbstractAssociations between human exposures to vehicular emissions (VE) and cardiopulmonary diseases have been found, with a dearth of information on particle cytotoxicity. This study exposes human lung alveolar epithelial (A549) cells to PM2.5 (particulate matter with aerodynamic diameter < 2.5 mu m) samples collected in a tunnel and investigates the oxidative and inflammatory responses. The cytotoxicity factor (CF) is used to normalize the VE cytotoxicity. The emission factors (EFs) were 27.2 +/- 12.0 mg vehicle(-1) km(-1) for PM2.5 and 4.93 +/- 1.67 mu g vehicle(-1) km(-1) for measured polycyclic aromatic hydrocarbons (PAHs). Higher EFs were found for high (4-6 rings) than low (2-3 rings) molecular-weight particulate PAHs. PM2.5 VE caused oxidative stress and inflammation of human lung cells. Organic carbon (OC), element carbon (EC), and several PAHs were significantly (p < 0.05) correlated with bioreactivity. Higher CFs were found when diesel vehicle counts were highest during the morning rush hour, implying that diesel-fueled VE were major contributors to cytotoxic effects. This study provides a broader understanding of the toxicity in an engine-exhaust dominated environment. (c) 2020 Elsevier Ltd. All rights reserved.
KeywordRespiratory effects Cytokines Bioreactivity Oxidative stress Inflammation potential
DOI10.1016/j.envpol.2020.114386
WOS KeywordPOLYCYCLIC AROMATIC-HYDROCARBONS ; AMBIENT PARTICULATE MATTER ; PORT THERMAL-DESORPTION ; ORGANIC-COMPOUNDS VOCS ; OXIDATIVE STRESS ; AIR-POLLUTION ; IN-VITRO ; RESPIRATORY SYMPTOMS ; CHEMICAL-COMPOSITION ; NOX EMISSIONS
Indexed BySCI ; SCI
Language英语
Funding ProjectResearch Grant Council of The Hong Kong Special Administrative Region China ; CUHK[14202817] ; U.S. Health Effects Institute[4947-RFPA14-1/15-1]
WOS Research AreaEnvironmental Sciences & Ecology
Funding OrganizationResearch Grant Council of The Hong Kong Special Administrative Region China ; CUHK ; U.S. Health Effects Institute
WOS SubjectEnvironmental Sciences
WOS IDWOS:000539426400058
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ieecas.cn/handle/361006/14942
Collection粉尘与环境研究室
Corresponding AuthorHo, Kin Fai
Affiliation1.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
2.Taipei Med Univ, Sch Resp Therapy, Coll Med, Taipei, Taiwan
3.Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA
4.Hong Kong Premium Serv & Res Lab, Hong Kong, Peoples R China
5.Chinese Acad Sci, Inst Earth Environm, State Key Lab Loess & Quaternary Geol SKLLQG, Xian, Peoples R China
6.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian, Peoples R China
7.Univ Chinese Acad Sci, Beijing, Peoples R China
8.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian 710049, Shaanxi, Peoples R China
9.Hong Kong Polytech Univ, Dept Civil & Environm Engn, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Niu, Xinyi,Chuang, Hsiao-Chi,Wang, Xiaoliang,et al. Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong[J]. ENVIRONMENTAL POLLUTION,2020,263:9.
APA Niu, Xinyi.,Chuang, Hsiao-Chi.,Wang, Xiaoliang.,Ho, Steven Sai Hang.,Li, Lijuan.,...&Ho, Kin Fai.(2020).Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong.ENVIRONMENTAL POLLUTION,263,9.
MLA Niu, Xinyi,et al."Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong".ENVIRONMENTAL POLLUTION 263(2020):9.
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