| Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong | |
| Niu, Xinyi1; Chuang, Hsiao-Chi2; Wang, Xiaoliang3; Ho, Steven Sai Hang3,4; Li, Lijuan5,6,7; Qu, Linli4; Chow, Judith C.3; Watson, John G.3; Sun, Jian8; Lee, Shuncheng9; Cao, Junji5,6; Ho, Kin Fai1 | |
| 通讯作者 | Ho, Kin Fai(kfho@cuhk.edu.hk) |
| 2020-08-01 | |
| 发表期刊 | ENVIRONMENTAL POLLUTION
 |
| ISSN | 0269-7491 |
| 卷号 | 263页码:9 |
| 摘要 | Associations between human exposures to vehicular emissions (VE) and cardiopulmonary diseases have been found, with a dearth of information on particle cytotoxicity. This study exposes human lung alveolar epithelial (A549) cells to PM2.5 (particulate matter with aerodynamic diameter < 2.5 mu m) samples collected in a tunnel and investigates the oxidative and inflammatory responses. The cytotoxicity factor (CF) is used to normalize the VE cytotoxicity. The emission factors (EFs) were 27.2 +/- 12.0 mg vehicle(-1) km(-1) for PM2.5 and 4.93 +/- 1.67 mu g vehicle(-1) km(-1) for measured polycyclic aromatic hydrocarbons (PAHs). Higher EFs were found for high (4-6 rings) than low (2-3 rings) molecular-weight particulate PAHs. PM2.5 VE caused oxidative stress and inflammation of human lung cells. Organic carbon (OC), element carbon (EC), and several PAHs were significantly (p < 0.05) correlated with bioreactivity. Higher CFs were found when diesel vehicle counts were highest during the morning rush hour, implying that diesel-fueled VE were major contributors to cytotoxic effects. This study provides a broader understanding of the toxicity in an engine-exhaust dominated environment. (c) 2020 Elsevier Ltd. All rights reserved. |
| 关键词 | Respiratory effects Cytokines Bioreactivity Oxidative stress Inflammation potential |
| DOI | 10.1016/j.envpol.2020.114386 |
| 关键词[WOS] | POLYCYCLIC AROMATIC-HYDROCARBONS ; AMBIENT PARTICULATE MATTER ; PORT THERMAL-DESORPTION ; ORGANIC-COMPOUNDS VOCS ; OXIDATIVE STRESS ; AIR-POLLUTION ; IN-VITRO ; RESPIRATORY SYMPTOMS ; CHEMICAL-COMPOSITION ; NOX EMISSIONS |
| 收录类别 | SCI ; SCI |
| 语种 | 英语 |
| 资助项目 | Research Grant Council of The Hong Kong Special Administrative Region China ; CUHK[14202817] ; U.S. Health Effects Institute[4947-RFPA14-1/15-1] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 项目资助者 | Research Grant Council of The Hong Kong Special Administrative Region China ; CUHK ; U.S. Health Effects Institute |
| WOS类目 | Environmental Sciences |
| WOS记录号 | WOS:000539426400058 |
| 出版者 | ELSEVIER SCI LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ieecas.cn/handle/361006/14942 |
| 专题 | 粉尘与环境研究室 |
| 通讯作者 | Ho, Kin Fai |
| 作者单位 | 1.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China 2.Taipei Med Univ, Sch Resp Therapy, Coll Med, Taipei, Taiwan 3.Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA 4.Hong Kong Premium Serv & Res Lab, Hong Kong, Peoples R China 5.Chinese Acad Sci, Inst Earth Environm, State Key Lab Loess & Quaternary Geol SKLLQG, Xian, Peoples R China 6.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian, Peoples R China 7.Univ Chinese Acad Sci, Beijing, Peoples R China 8.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian 710049, Shaanxi, Peoples R China 9.Hong Kong Polytech Univ, Dept Civil & Environm Engn, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, Xinyi,Chuang, Hsiao-Chi,Wang, Xiaoliang,et al. Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong[J]. ENVIRONMENTAL POLLUTION,2020,263:9. |
| APA | Niu, Xinyi.,Chuang, Hsiao-Chi.,Wang, Xiaoliang.,Ho, Steven Sai Hang.,Li, Lijuan.,...&Ho, Kin Fai.(2020).Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong.ENVIRONMENTAL POLLUTION,263,9. |
| MLA | Niu, Xinyi,et al."Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong".ENVIRONMENTAL POLLUTION 263(2020):9. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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