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Pulmonary inflammation induced by low-dose particulate matter exposure in mice
Chan, Yik Lung1,2; Wang, Baoming1,2; Chen, Hui1; Ho, Kin Fai3; Cao, Junji4; Hai, Guo5; Jalaludin, Bin6; Herbert, Cristan7,8; Thomas, Paul S.7,8; Saad, Sonia9; Oliver, Brian Gregory George1,2
通讯作者Chan, Yik Lung(Yik.chan@uts.edu.au)
2019-09-01
发表期刊AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
ISSN1040-0605
卷号317期号:3页码:L424-L430
摘要Air pollution is a ubiquitous problem and comprises gaseous and particulate matter (PM). Epidemiological studies have clearly shown that exposure to PM is associated with impaired lung function and the development of lung diseases, such as chronic obstructive pulmonary disease and asthma. To understand the mechanisms involved, animal models are often used. However, the majority of such models represent high levels of exposure and are not representative of the exposure levels in less polluted countries, such as Australia. Therefore, in this study, we aimed to determine whether low dose PM10 exposure has any detrimental effect on the lungs. Mice were intranasally exposed to saline or traffic-related PM10 (1 mu g or 5 mu g/day) for 3 wk. Bronchoalveolar lavage (BAL) and lung tissue were analyzed. PM10 at 1 mu g did not significantly affect inflammatory and mitochondrial markers. At 5 mu g, PM10 exposure increased lymphocytes and macrophages in BAL fluid. Increased NACHT, LRR and PYD domains-containing protein 3 (NLRP3) and IL-1 beta production occurred following PM10 exposure. PM10 (5 mu g) exposure reduced mitochondrial antioxidant manganese superoxide (antioxidant defense system) and mitochondrial fusion marker (OPA-1), while it increased fission marker (Drp-1). Autophagy marker light-chain 3 microtubule-associated protein (LC3)-II and phosphorylated-AMPK were reduced, and apoptosis marker (caspase 3) was increased. No significant change of remodeling markers was observed. In conclusion, a subchronic low-level exposure to PM can have an adverse effect on lung health, which should be taken into consideration for the planning of roads and residential buildings.
DOI10.1152/ajplung.00232.2019
关键词[WOS]NLRP3 INFLAMMASOME ; OXIDATIVE STRESS ; AUTOPHAGY ; PARTICLES ; RESPONSES
收录类别SCI ; SCI
语种英语
资助项目SPHERE, RCG of the Hong Kong Special Administrative Region[CRF/C5004-15E] ; Strategic Focus Area scheme of The Research Institute for Sustainable Urban Development at The Hong Kong Polytechnic University[1-BBW9] ; National Natural Science Foundation of China[81750110554] ; National Health and Medical Research Council Australia[APP1110368] ; China Scholarship Council
WOS研究方向Physiology ; Respiratory System
项目资助者SPHERE, RCG of the Hong Kong Special Administrative Region ; Strategic Focus Area scheme of The Research Institute for Sustainable Urban Development at The Hong Kong Polytechnic University ; National Natural Science Foundation of China ; National Health and Medical Research Council Australia ; China Scholarship Council
WOS类目Physiology ; Respiratory System
WOS记录号WOS:000485282700011
出版者AMER PHYSIOLOGICAL SOC
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/13476
专题粉尘与环境研究室
通讯作者Chan, Yik Lung
作者单位1.Univ Technol Sydney, Sch Life Sci, Sydney, NSW, Australia
2.Woolcock Inst Med Res, Resp Cellular & Mol Biol, Sydney, NSW, Australia
3.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian, Shaanxi, Peoples R China
5.Hong Kong Polytech Univ, Dept Civil & Environm Engn, Air Qual Studies, Hong Kong, Peoples R China
6.Univ New South Wales, Ingham Inst Appl Med Res, Sydney, NSW, Australia
7.Univ New South Wales, Fac Med, Dept Pathol, Sch Med Sci, Sydney, NSW, Australia
8.Univ New South Wales, Fac Med, Prince Wales Clin Sch, Sydney, NSW, Australia
9.Royal North Shore Hosp, Renal Grp Kolling Inst, St Leonards, NSW, Australia
推荐引用方式
GB/T 7714
Chan, Yik Lung,Wang, Baoming,Chen, Hui,et al. Pulmonary inflammation induced by low-dose particulate matter exposure in mice[J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY,2019,317(3):L424-L430.
APA Chan, Yik Lung.,Wang, Baoming.,Chen, Hui.,Ho, Kin Fai.,Cao, Junji.,...&Oliver, Brian Gregory George.(2019).Pulmonary inflammation induced by low-dose particulate matter exposure in mice.AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY,317(3),L424-L430.
MLA Chan, Yik Lung,et al."Pulmonary inflammation induced by low-dose particulate matter exposure in mice".AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 317.3(2019):L424-L430.
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