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Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China
Niu, Xinyi1,2; Ho, Kin Fai1; Chuang, Hsiao-Chi3; Sun, Jian4; Huang, Yu2,5; Hu, Tafeng2,5; Xu, Hongmei6; Duan, Jing2,5; Lui, Ka Hei1; Cao, Junji2,5
通讯作者Ho, Kin Fai(kfho@cuhk.edu.hk) ; Cao, Junji(cao@loess.llqg.ac.cn)
2019-11-01
发表期刊ATMOSPHERIC ENVIRONMENT
ISSN1352-2310
卷号216页码:8
摘要The chemical and bioreactivity properties of fine particulate matter (PM2.5) in indoor and outdoor environments in Xi'an were characterized, and the lung function of various participants was investigated. The concentrations of polycyclic aromatic hydrocarbons (PAHs), oxygenated polycyclic aromatic hydrocarbons, and nitrated polycyclic aromatic hydrocarbons were higher in outdoor environments than in indoor environments; in addition, urban areas had higher concentrations of these compounds than did suburban areas, with fossil fuel combustion likely being the primary source. Moreover, PM2.5-induced inflammation was higher in urban areas than in suburban areas. Indoor environments with coal combustion emissions showed relatively higher oxidative potential and inflammation. Moderate (phenanthrene) to strong (acenaphthylene and benzo(a)pyrene) correlations were observed between selected PAHs against interleukin 6 (IL-6), 8-hydroxy-desoxyguanosine (8-OHdG), and necrosis factor-alpha (TNF-alpha). Moreover, 9-fluorenone, 9,10-anthraquinone, and 5,12-naphthacenequinone exhibited higher oxidative stress and inflammation than did their parent PAHs. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively correlated with 8-OHdG, and FEV1/FVC was negatively correlated with TNF-alpha and IL-6. These findings-which integrates PM2.5 with lung function and bioreactivity analyses-suggest that coal burning, especially indoors, could elevate the cytotoxicity of PM2.5 to the occupants and that chronic exposure may lead to a decline in lung function.
关键词PM2.5 PAHs Bioreactivity Lung function
DOI10.1016/j.atmosenv.2019.116929
关键词[WOS]PARTICULATE MATTER PM2.5 ; HOUSEHOLD COAL COMBUSTION ; LUNG-CELLS L132 ; AIR-POLLUTION ; HYDROCARBONS PAHS ; OXYGENATED-PAHS ; CHEMICAL-COMPOSITION ; SOURCE APPORTIONMENT ; OXIDATIVE STRESS ; OUTDOOR AIR
收录类别SCI ; SCI
语种英语
资助项目Research Grants Council of the Hong Kong Special Administrative Region China ; CUHK[14212116] ; Ministry of Science and Technology of China[2013FY112700] ; National Program on Basic Research Project of China[2013FY112500]
WOS研究方向Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences
项目资助者Research Grants Council of the Hong Kong Special Administrative Region China ; CUHK ; Ministry of Science and Technology of China ; National Program on Basic Research Project of China
WOS类目Environmental Sciences ; Meteorology & Atmospheric Sciences
WOS记录号WOS:000525864200018
出版者PERGAMON-ELSEVIER SCIENCE LTD
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ieecas.cn/handle/361006/12560
专题粉尘与环境研究室
通讯作者Ho, Kin Fai; Cao, Junji
作者单位1.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian, Peoples R China
3.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan
4.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian, Peoples R China
5.Chinese Acad Sci, Inst Earth Environm, SKLLQG, Xian, Peoples R China
6.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian, Peoples R China
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Niu, Xinyi,Ho, Kin Fai,Chuang, Hsiao-Chi,et al. Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China[J]. ATMOSPHERIC ENVIRONMENT,2019,216:8.
APA Niu, Xinyi.,Ho, Kin Fai.,Chuang, Hsiao-Chi.,Sun, Jian.,Huang, Yu.,...&Cao, Junji.(2019).Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China.ATMOSPHERIC ENVIRONMENT,216,8.
MLA Niu, Xinyi,et al."Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China".ATMOSPHERIC ENVIRONMENT 216(2019):8.
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